The purpose of this study was stress in a middle-aged woman with depression. The subject was a 50-year-old, middle-aged woman living in A city who was diagnosed with depression but now she voluntarily has stopped taking medicine. The program was conducted twice or three times a week for 60 minutes in each in total of 17 times from July to August, 2019. The research tools were depression scale, anxiety scale and parenting stress scale and there was a comparative analysis for pre- and post- changes of DAS test, K-HTP test and PITR test as a projective test. In addition, there was a qualitative analysis for transition process of subject's depression, anxiety, parenting stress in each phases and sessions. The results are the following. First of all, a positive change on the middle-aged woman's depression was observed in the depression scale and DAS test. Secondly, it was verified that it provides a positive effect on the anxiety scale and K-HTP test. Thirdly, a positive change on parenting stress was observed through the parenting stress scale and PITR test. Fourth, in qualitative analysis for each phase and session, she perceived her husband positively and accepted him and confirmed her parenting attitude was overprotecting her children. Therefore, it was verified that art therapy is effective on reduction of a middle aged woman's depression, anxiety and parenting stress and it would be helpful for developing art therapy programs for middle-aged women with depression.